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Post by Hot Christian Stocks on Feb 18, 2014 9:34:26 GMT -5
$NVLX Dr. Mark L. Rabe has something in common with 18 members of Congress - All of them want marijuana reclassified NEW YORK, NY -- (Marketwired) -- 02/14/14 Nuvilex, Inc.'s (OTCQB: NVLX) Dr. Mark L. Rabe has something in common with 18 members of Congress. All of them want marijuana reclassified from its current listing as a dangerous drug with no medical value, and they want President Obama to use his authority to make that change by removing marijuana from the Schedule I category. Currently marijuana is viewed in the same category as drugs like heroin and LSD, and in a letter sent to the president this week, 18 legislators said this status "makes no sense." In the letter to President Obama, the 18 members of Congress said, "We request that you instruct Attorney General Holder to delist or classify marijuana in a more appropriate way, at the very least eliminating it from Schedule I or II." Nuvilex appointed Dr. Rabe, a leading figure in the medical marijuana field, as the Chairman of the Scientific Advisory Board of Medical Marijuana Sciences, the company's wholly-owned subsidiary formed to house its work in the Cannabis industry. Dr. Rabe agrees with the letter to the president. "The most important component of legalization is that the Cannabis plant and its medicinal cannabinoid components need to be removed from the federal "Schedule I" category. Because of this designation, doctors currently cannot legally treat patients with cannabinoids. Rather, they can only "recommend" the use of medical marijuana, which leaves patients on their own to obtain their own medicine and treat themselves." The Congressional letter went on to state, "Classifying marijuana as Schedule I at the federal level perpetuates an unjust and irrational system. Schedule I recognizes no medical use, disregarding both medical evidence and the laws of nearly half of the states that have legalized medical marijuana." Dr. Rabe realizes this is the first step to Nuvilex beginning its work with Cannabis and added, "Removal of the Schedule I designation would also allow for properly designed placebo-controlled double blind studies to occur in order to advance the use of cannabinoids as medicine." www.stockwatch.com/News/Item.aspx?bid=U-i1090099-U%3aNVLX-20140214&symbol=NVLX®ion=U |
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Post by Hot Christian Stocks on Feb 19, 2014 9:07:12 GMT -5
$NVLX Pancreatic Cancer Treatment Readies to Challenge Eli Lilly and Celgene in Late-Phase Clinical Trials Nuvilex, Inc. (OTCQB: NVLX) is a small biotech firm in Silver Spring, Maryland, that hopes to soon be mentioned with much larger biotechnology and pharmaceutical companies like Eli Lilly and Celgene. If the company's pancreatic cancer treatment that combines the proprietary cellulose-based live-cell encapsulation technology known as Cell-in-a-Box with the anti-cancer drug ifosfamide can produce the same or better data in its upcoming late-phase clinical trials in advanced, inoperable pancreatic cancer than were seen with this same combination in two earlier independent Phase II trials, then not only will it be mentioned with those larger companies, Nuvilex's treatment will likely be the new "gold standard" for the disease. So far, Nuvilex has methodically gone about its business laying the groundwork for its future trials. It's a process that demands a meticulous approach, especially when the outcome could lead to billions of dollars. Eli Lilly has realized more than $10 billion with its cancer drug Gemzar® (gemcitabine) since it was approved in 1996 as the gold standard for advanced, inoperable pancreatic cancer. It wasn't really until Celgene's drug Abraxane (a nanoparticle formulation of the widely used drug Taxol with albumin) in combination with gemcitabine was approved in 2013 that patients had a better option than single-agent gemcitabine. Approval of Celgene's treatment was undoubtedly assisted by the involvement of Dr. Daniel D. Von Hoff, who was also the principal investigator for the first clinical trial of gemcitabine and is considered among the nation's leading authorities on pancreatic cancer. In his role as Consultant to Celgene, Dr. Von Hoff helped to get approval for Celgene's Abraxane-gemcitabine combination fast-tracked by showing the FDA that there is an urgent need for better treatments for advanced pancreatic cancer. Now it is Nuvilex's turn. The company's advanced pancreatic cancer treatment that combines the Cell-in-a-Box technology with ifosfamide has provided better results than both gemcitabine alone and the Abraxane-gemcitabine combination. Those results included an increase of about 4 months in median survival time over gemcitabine alone versus the 1.8 months seen with the Abraxane-gemcitabine combination. The results also included a 100% increase in the one-year survival rate as compared to gemcitabine versus a 59% increase for the Abraxane-gemcitabine combination. The results obtained with Nuvilex's treatment are even more noteworthy given that only one-third of the dose of ifosfamide normally used to treat other types of cancer was used in the Phase II pancreatic cancer trials. Another apparent advantage for Nuvilex's treatment compared to the Abraxane-gemcitabine combination concerns the side effects (toxicities) associated with both treatments. Significant and severe drug-associated toxicities were seen with the Abraxane-gemcitabine combination, whereas with Nuvilex's treatment, side effects were essentially non-existent. The lack of side effects from the Cell-in-a-Box-ifosfamide combination is undoubtedly related to the low dose of ifosfamide used. For Nuvilex's investors, the good news is that, once funding is secured for the late- phase clinical trials, companies like Celgene are likely to take notice. After all, the global biopharmaceutical was able to quickly get the Abraxane-gemcitabine combination approved by showing both an urgent need for better pancreatic cancer treatments and better results than those seen 17 years before with the prior gold standard Gemzar. Well, nothing has changed - there is still a need, and Nuvilex may just prove again its treatment consisting of the combination of Cell-in-a-Box with ifosfamide can produce even better results than Celgene's recently approved therapy. www.stockwatch.com/News/Item.aspx?bid=U-i1091081-U%3aNVLX-20140219&symbol=NVLX®ion=U |
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Post by Hot Christian Stocks on Feb 20, 2014 9:07:27 GMT -5
$NVLX Nuvilex Announces $27 Million Funding Commitment With Institutional Investor to Advance Late Phase Clinical Trials SILVER SPRING, Md., Feb. 20, 2014 (GLOBE NEWSWIRE) -- Nuvilex, Inc. (OTCQB:NVLX), an international biotechnology company providing cell and gene therapy solutions for the treatment of deadly diseases, announced today that it has entered into a stock purchase agreement with Lincoln Park Capital Fund, LLC (Lincoln Park), a Chicago-based institutional investor. Lincoln Park initially purchased 8 million shares of Nuvilex's common stock at $0.25 per share for $2 million and has committed to invest, at the sole option of Nuvilex, up to an additional $25 million of equity capital over the term of the purchase agreement. The proceeds from this investment will be used for Nuvilex's late-stage clinical trials in advanced inoperable pancreatic cancer, for research into the use of constituents of marijuana in the emerging medical marijuana arena and for general operating purposes. Kenneth L. Waggoner, the CEO and President of Nuvilex, commented, "Our stock purchase agreement with Lincoln Park gives Nuvilex the flexibility to access capital over time at prevailing market prices and as our needs arise. The initial funding helps us to proceed with our planned late-stage pancreatic cancer clinical trials. The $2 million initial investment also reflects the commitment to Nuvilex and our live-cell encapsulation platform for developing treatments for cancer and diabetes." During the 36-month term of the stock purchase agreement, Nuvilex, at its sole discretion, has the right to sell Lincoln Park up to an additional $25 million of Nuvilex common stock in amounts as described in the agreement and subject to certain conditions which include the effectiveness of a registration statement with the U.S. Securities and Exchange Commission (SEC) covering the sale of the shares that may be issued to Lincoln Park. Nuvilex controls the timing and amount of any future investment. Lincoln Park is obligated to make purchases if and when Nuvilex decides. Under the terms of the stock purchase agreement, there are no upper limits on the price Lincoln Park may pay to purchase Nuvilex's common stock. The purchase price of the shares related to any future investments will be based on the prevailing market prices of Nuvilex's shares immediately preceding a notice of sale to Lincoln Park. Lincoln Park has agreed not to cause or engage in any direct or indirect short selling or hedging of Nuvilex's common stock. The stock purchase agreement may be terminated by Nuvilex at any time at its sole discretion and without any monetary cost to Nuvilex. A more detailed description of the stock purchase agreement is set forth in the Nuvilex's Current Report on Form 8-K already filed with the SEC and which Nuvilex encourages be reviewed carefully. This press release does not constitute an offer to sell or a solicitation of an offer to buy the securities in any offering, nor will there be any sale of securities of Nuvilex in any jurisdiction in which such offer solicitation or sale are unlawful prior to registration or qualification under securities laws of any such jurisdiction. www.stockwatch.com/News/Item.aspx?bid=U-z10069225-U%3aNVLX-20140220&symbol=NVLX®ion=U |
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Post by Hot Christian Stocks on Feb 21, 2014 10:42:08 GMT -5
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Post by Hot Christian Stocks on Feb 24, 2014 9:18:26 GMT -5
$NVLX - Chicago Investment Firm Assumes $27 Million Risk to Help Nuvilex Unseat Celgene and Eli LillyNEW YORK, NY -- (Marketwired) -- 02/24/14 Lincoln Park Capital (LPC) purchased 8 million restricted shares of Nuvilex, Inc. (OTCQB: NVLX) in exchange for an initial $2 million out of what can be viewed as a $27 million "pot of money" to advance the company's late-phase pancreatic cancer clinical trials. Notice we said restricted shares, that's right, LPC has put a great deal of its money on the line with a number of built in protections for Nuvilex. But, is this investment really a risk? It appears the Chicago-based firm knows exactly what the future could hold for Nuvilex, and they're comfortable with paying a premium price to become a long-term investor right along with many others who believe in the small biotechnology firm. Much like its investment with Elite Pharmaceuticals in April 2013 that has since seen that company's price per share rise to highs of over 500%, LPC could benefit greatly from a much higher price tag when Nuvilex enters late-phase clinical trials, completes those trials and applies for approval with the FDA. LPC has at least two members of its team, Dr. Michael Beaubaire and Jonathan Cope, who are biotech savvy and have clearly seen the results from two previous independent Phase II clinical trials using the pancreatic cancer treatment that combines Cell-in-a-Box live-cell encapsulation with the anti-cancer drug ifosfamide - a treatment recently licensed by Nuvilex. Those results indicated that this combination treatment outperformed Eli Lilly's long-time single-agent treatment for advanced inoperable pancreatic cancer, Gemzar® (gemcitabine), and Celgene's recently approved drug Abraxane (a nanoparticle formulation of the widely used drug Taxol with albumin) in combination with gemcitabine. Results from the Cell-in-a-Box-ifosfamide combination in patients with advanced pancreatic cancer included almost a doubling of median survival time from 5.7 months for Gemzar to the 11 months seen with the combination; this compares to the 8.5 months seen with the Abraxane-gemcitabine combination. The results also included a 100% increase in the one-year survival rate as compared to gemcitabine versus a 59% increase for the Abraxane-gemcitabine combination. The results obtained with the Cell-in-a-Box-ifosfamide combination are even more noteworthy given that only one-third of the dose of ifosfamide normally used to treat other types of cancer was used in the Phase II pancreatic cancer trials. It is likely that this lower dosage also contributed to the fact that there were no significant side effects from the Cell-in-a-Box-ifosfamide combination. However, there were significant and severe drug-associated toxicities seen with both single-agent Gemzar and with the Abraxane-gemcitabine combination. LPC realizes that if these results can be repeated in Nuvilex's planned late-phase clinical trials, then the FDA approved treatments developed by biopharmaceutical giants Celgene and Eli Lilly will surely be unseated as the "gold standard" treatment for advanced inoperable pancreatic cancer. Keep in mind Eli Lilly has parlayed gemcitabine into more than $10 billion. Nuvilex owns the exclusive worldwide rights to use the Cell-in-a-Box technology to develop treatments for any type of cancer and for treatments for diabetes as well. The technology has already shown equally amazing results in animal studies in both breast cancer and diabetes. So, it doesn't stop at pancreatic cancer for Nuvilex or any investor with a position in the company's stock, and that includes Lincoln Park Capital. www.stockwatch.com/News/Item.aspx?bid=U-i1092297-U%3aNVLX-20140224&symbol=NVLX®ion=U
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Post by Hot Christian Stocks on Feb 25, 2014 9:31:50 GMT -5
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Post by Hot Christian Stocks on Feb 26, 2014 7:40:49 GMT -5
$NVLX - Comprehensive Analyst Report Answers Vital Questions for Shareholders, by BrokerBank Securities, Inc. NEW YORK, Feb. 26, 2014 /PRNewswire/ -- Nuvilex, Inc. (OTCQB: NVLX) owns exclusive rights to a cancer treatment platform that has successfully completed Phase 2 clinical trials for inoperable pancreatic cancer. Nuvilex also owns rights to the same platform to treat diabetes, and the company also has a medical marijuana subsidiary slated to begin cancer research and development using cannabidiol. With each of the key target markets representing multi-billion-dollar opportunities, Nuvilex offers investors multiple opportunities for success and should trade at a valuation that reflects its current development progress to date. The company primarily focuses on the advancement of its treatment for advanced, inoperable pancreatic cancer that combines the Cell-in-a-Box technology with the anti-cancer drug ifosfamide. This treatment has completed Phase 1/2 clinical trials. The company, through its subsidiary, Medical Marijuana Sciences, Inc., uses constituents of Cannabis in developing treatments for cancer, particularly those that are difficult to treat . With the excitement and buzz circulating around this stock in the last few months there is a lot of speculation as to the validity of NVLX. To help investors get a better grasp on NVLX, we have decided to offer a comprehensive research report below. This comprehensive research report is authored by a Chartered Financial Analyst and includes vital information that every shareholder of NVLX must read. There is no charge for this report. Included in the report you will find recent highlights of NVLX, Overview of the Global Pharmaceuticals Industry, U.S Food and Drug Administration's (FDA) Approval process for NVLX products, in-depth description of company history, pipeline drugs and current stage, financial position, valuation of company, analyst summary, and price target: bit.ly/NVLX-PriceTarget copy and paste may be required www.stockwatch.com/News/Item.aspx?bid=U-prDE72008-U%3aNVLX-20140226&symbol=NVLX®ion=U |
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Post by Hot Christian Stocks on Feb 27, 2014 9:18:49 GMT -5
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Post by Hot Christian Stocks on Feb 28, 2014 9:40:00 GMT -5
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Post by Hot Christian Stocks on Mar 3, 2014 9:23:17 GMT -5
$NVLX - Nuvilex Funding Has Investors Preparing for Milestone Announcements in Late-Phase Clinical Trials NEW YORK, NY -- (Marketwired) -- 03/03/14 Nuvilex (OTCQB: NVLX) investors who have patiently waited for the R&D biotech to reach a point where late-phase clinical trials were a reality, are probably relishing these truly exciting times after a Chicago-based institutional investor committed to fund $27 million dollars toward the company's clinical trials in advanced inoperable pancreatic cancer. Leading up to the aforementioned clinical trials, investors can expect to see a list of milestone developments unfold, and for those who consider themselves biotech junkies, they know this is when the fun begins. It is likely just a matter of time now before investors start hearing words like Good Manufacturing Practices (GMP), Principal Investigator (PI), Protocol, Contract Research Organization (CRO), Study Sites, etc., and with each of these milestone developments, Nuvilex draws closer to the actual patient recruitment process and eventual patient enrollment for the clinical trials. Additional news events to pay attention to will be the cloning of the cancer-drug-activating cells that are required for the clinical trials. The cloning began last November at Inno Biologics, and this process is necessary to obtain the large numbers of cells required for the late-phase trials. Also, locating facilities in which the encapsulation of these large numbers of cells can be done according to GMP standards is also crucial, and the company says GMP compliance is an absolute requirement for drug regulatory authorities. With funding now flowing into the company, expect to see activity start to pick up. For those unfamiliar with where Nuvilex is heading, here's a quick recap. Nuvilex acquired the exclusive worldwide rights to use the Cell-in-a-Box live-cell encapsulation technology to develop treatments for diabetes and any form of cancer. Now the company is preparing to advance late-phase clinical trials using the licensed pancreatic cancer treatment that combines Cell-in-a-Box with the anti-cancer drug ifosfamide to build upon two previous independent Phase II clinical trials. The excitement for the company and its investors is that, in those two completed Phase II trials, the treatment that Nuvilex owns the rights to use outperformed Eli Lilly's long-time single-agent treatment for advanced inoperable pancreatic cancer, Gemzar® (gemcitabine), and Celgene's recently approved drug Abraxane (a nanoparticle formulation of the widely used drug Taxol with albumin) in combination with gemcitabine. If Nuvilex's late-phase clinical trials can continue to outperform Celgene's therapy, then the company's treatment will likely be the new "gold standard" for the disease -- a designation that earned Eli Lilly's drug Gemzar more than $10 billion when it was the "gold standard" for advanced inoperable pancreatic cancer. It is numbers like this that make it clear why so many have remained patient with their Nuvilex investment, and we haven't even begun to discuss the company's future in diabetes! www.stockwatch.com/News/Item.aspx?bid=U-i1094446-U%3aNVLX-20140303&symbol=NVLX®ion=U |
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Post by Hot Christian Stocks on Mar 4, 2014 9:17:42 GMT -5
The excitement for $NVLX - and its investors is that, in those two completed Phase II trials, the treatment that Nuvilex owns the rights to use outperformed Eli Lilly's long-time single-agent treatment for advanced inoperable pancreatic cancer, Gemzar® (gemcitabine), and Celgene's recently approved drug Abraxane (a nanoparticle formulation of the widely used drug Taxol with albumin) in combination with gemcitabine www.stockwatch.com/News/Item.aspx?bid=U-i1094446-U%3aNVLX-20140303&symbol=NVLX®ion=U |
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Post by Hot Christian Stocks on Mar 6, 2014 8:18:42 GMT -5
$NVLX Recent Events Effectively De-Risk Nuvilex, Inc. BALTIMORE, Maryland, March 6, 2014 /PRNewswire/ --Goldman Small Cap Research, a stock market research firm focused on the small cap and micro cap sectors, recently published a new research update on Nuvilex Inc. (OTCQB: NVLX). In the update, senior analyst Rob Goldman outlines his latest thesis. "In our view, with institutional funding in place to a potential $27 million, Nuvilex has been transformed from an also-ran to a soon-to-be-prime time player in the biotech and medical marijuana arenas. Moreover, this funding agreement validates the Company's technology and effectively de-risks the stock." Nuvilex is a biotechnology company with the rights to a novel cellulose-based live-cell encapsulation technology, called Cell-in-a-Box™, that will be used as a platform upon which treatments for several types of cancer, including advanced, inoperable pancreatic cancer, and diabetes are being built. Nuvilex's treatment for pancreatic cancer involves the use of the widely used anticancer prodrug, ifosfamide, together with encapsulated live cells that convert ifosfamide into its active or "cancer-killing" form. Nuvilex's subsidiary, Medical Marijuana Sciences, Inc., is dedicated to the development of cancer treatments based upon the well-known chemical constituents of marijuana. Nuvilex is exploring ways in which the Cell-in-a-Box™ technology may play a role in these efforts. According to Goldman, now that an institution has validated the company, attention will be focused on fundamentals and a series of future milestones and executable events, which means a higher future valuation for the company and all three of its treatment categories: cancer, diabetes, and medicinal marijuana. Moreover, since all three categories address high profile, multi-billion dollar markets, the associated future valuation adjustments could be substantial as milestone events are executed. www.stockwatch.com/News/Item.aspx?bid=U-prenUK201403052285A-U%3aNVLX-20140306&symbol=NVLX®ion=U |
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Post by Hot Christian Stocks on Mar 6, 2014 13:33:48 GMT -5
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Post by Hot Christian Stocks on Mar 7, 2014 9:06:14 GMT -5
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Post by Hot Christian Stocks on Mar 10, 2014 8:10:52 GMT -5
$NVLX - Nuvilex appointed Dr. Rabe, a leading figure in the medical marijuana field quoted in article about a minister's daughter stating - Cannabis 'a gift from God' "Patients often come into my office and drop down a brown bag full of pill bottles on my desk and say, 'I'm off Oxycodone; I'm off muscle relaxants. I'm off Ambien; I'm off Trazodone,' because medical cannabis does the job better," said Rabe, who runs Centric Wellness in San Diego www.cnn.com/2014/03/07/health/cannabis-pain/ |
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